Summary: Lead statistical strategy and design for product development and regulatory submissions in cardiovascular, renal, and metabolism, driving meaningful patient benefit. Highlights: 1. Shape statistical strategy for advancing medicines globally 2. Lead project statistical design, delivery, and interpretation 3. Influence decisions across a rich pipeline with tangible impact Are you ready to shape the statistical strategy that advances medicines in cardiovascular, renal and metabolism, bringing meaningful benefit to patients worldwide? You will join a fast\-moving, collaborative community of statisticians and data scientists, working on complex challenges that demand curiosity, resilience and smart risk\-taking. Your leadership will influence statistical strategy or technical activities related to design, delivery and interpretation, high level internal governance committees and/or regulatory submissions of a project. Do you want your work to drive decisive choices and successful submissions across a rich pipeline? Step into a position where your expertise is trusted, your voice matters and your impact is tangible. **Accountabilities:** The Statistical Science Director will typically lead a project. The accountabilities for supporting projects directly include: * Lead the statistical design and strategy to product development plans, clinical studies, regulatory strategy, health technology assessment and/or commercial activities as appropriate for the stage of the product * Lead the statistical content and ensure quality for study designs, documents, delivery and interpretation and submission * Quantify the benefit, risk, value and uncertainty of the emerging product profile and can communicate these effectively within the team * Provide global leadership to others and direct project work delivered by internal and external staff * Partner with CROs to ensure delivery to quality and time * Represent AZ externally which may include health authorities, advisory boards, conferences, workshops and/or payer interactions * Maintain knowledge of statistical methodology in relevant areas and promote, investigate and implement novel statistical approaches * Represent statistical strategy and decision making at internal decision\-making governance including review boards, therapy area leadership teams and internal governance committees * Mentor/coach and support the technical education and training of Statistics staff **Essential Qualifications:** * MSc/PhD in Statistics, Mathematics (containing a substantial statistical component), or recognised equivalent to stats MSc * Track record of background in leading independently * Exemplary technical skills **Desirable Qualifications:** * TA or disease area knowledge expertise * Exposure to business development opportunities (e.g.in licencing) * Project management skills * Proficiency in programming SAS and/or R and Python When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life\-changing medicines. In\-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. **Why AstraZeneca** Here, your statistical leadership fuels progress for patients and the business. You will work across a diverse pipeline with modern tools and encouraging peers, tackling complex questions that demand creative, high\-integrity solutions. We bring a diverse set of minds together, invite challenge, and recognize learning as we move fast from idea to impact. Our culture values kindness alongside ambition. You have the freedom to experiment and access to influence. You will enjoy the happiness of seeing your work unlock decisions that bring medicines to those who need them most. Bring your expertise to a high\-impact pipeline—take the lead on programs that matter and shape the future of CVRM development today.